Molaei, M., Vandehoef, C., Karpac, J. (2019). NF-kB shapes metabolic adaptation by attenuating Foxo-mediated lipolysis in Drosophila. Developmental Cell , 49(5): 802-810. e6. 

Mlih, M., Khericha, M., Birdwell, C., West, AP., Karpac, J. (2018). A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis. PLoS Biology , 16(7): e2005796.

 

Fuentes, NR., Mlih, M., Barhoumi, R., Fan, YY., Hardin, P., Steele, TJ., Behmer, S., Prior, IA., Karpac, J., Chapkin, RS. (2018). Long chain n-3 fatty acids attenuate oncogenic KRas-driven proliferation by altering plasma membrane nanoscale proteolipid composition. Cancer Research , DOI: 10.1158/0008-5472.

 

Zhao, X., Karpac, J(2017). Muscle directs diurnal energy homeostasis through a myokine-dependent hormone module in Drosophila. Current Biology , 27(13): 1941-1955. F1000Prime

Luis Miguel, N., Wang, L., Ortega, M., Deng, H., Katewa, SD., Wai-Lun Li, P., Karpac, J., Jasper, H., Kapahi, P. (2016). Intestinal IRE1 is required for increased triglyceride metabolism and longer lifespan under dietary restriction. Cell Reports, 17(5): 1207-1216.   

Guo, L.*, Karpac, J.*, Tran, S., Jasper, H. (2014). PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan. Cell, 156(1-2):109-122. *equal contribution     

 

Wang, L.*, Karpac, J.*, Jasper, H. (2014). Promoting longevity by maintaining metabolic and proliferative homeostasis. J Exp Biol., 217(Pt 1): 109-18. *equal contribution    

 

Karpac, J.#, Biteau, B., Jasper, H. (2013). Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Reports, 4(6): 1250-1261. #corresponding author

 

Karpac, J., Jasper, H. (2013). Aging: Seeking mitonuclear balance. Cell, 154(2): 271-273.

 

Kapuria, S., Karpac, J., Biteau, B., Hwangbo, DS., Jasper, H. (2012). Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. PLoS Genetics, 8(11): e1003045.

 

Karpac, J., Younger, A., Jasper, H. (2011). Dynamic coordination of innate immune signaling and Insulin signaling regulates systemic responses to localized DNA damage. Developmental Cell, 20(6): 841-54.  

 

Karpac, J., Jasper, H. (2011). Metabolic Homeostasis: HDACs Take Center Stage. Cell, 145(4): 497-9.

 

Biteau, B., Karpac, J., Hwangbo, D., and Jasper, H. (2010). Regulation of Drosophila lifespan by JNK signaling. Exp Gerontol, 46(5): 349-54.

 

Biteau, B.*, Karpac, J.*, Supoyo, S., DeGennaro, M., Lehmann, R., and Jasper, H. (2010). Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genetics, 6(10): e1001159. *equal contribution

 

Karpac, J., Hull-Thompson, J., Falleur, M., and Jasper, H. (2009). JNK signaling in insulin producing cells is required for adaptive responses to stress in Drosophila. Aging Cell, 8 288-295.

 

Karpac, J., and Jasper, H. (2009). Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol Metab, 20, 100-106.

 

Karpac, J., Kern, A., Kim, S., Brush, S., Bui, S., Hunnewell, P. & Hochgeschwender, U. (2008). Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. Am J Physiol Endocrinol Metab, 295(2): E446-55.

 

Karpac, J., Kern, A. & Hochgeschwender, U. (2007). Pro-opiomelanocortin peptides and the adrenal gland. Mol Cell Endocrinol, 265-266:29-33.

 

Karpac, J., Ostwald, D., Li, G. Y., Bi, S., Hunnewell, P., Brennan, M.B. & Hochgeschwender, U. (2006). Pro-opiomelanocortin Heterozygous and Homozygous Null Mutant Mice Develop Pituitary Adenomas. Cell Mol Biol, 52, 47-52.

 

Ostwald, D., Karpac, J. & Hochgeschwender, U. (2006). Effects on hippocampus of lifelong absence of glucocorticoids in the pro-opiomelanocortin null mutant mouse reveal complex relationship between glucocorticoids and hippocampal structure and function. J Mol Neurosci, 28, 291-302.

 

Karpac, J., Ostwald, D., Bui, S., Hunnewell, P., Shankar, M. & Hochgeschwender, U. (2005). Development, maintenance, and function of the adrenal gland in early post-natal pro-opiomelanocortin-null mutant mice. Endocrinology, 146, 2555-62.